Liposomal delivery systems for intestinal lymphatic drug transport
نویسندگان
چکیده
Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposomal formulations have attracted particular attention because they can stimulate the production of chylomicrons and the incorporated drugs readily associate with enterocyte-derived chylomicrons, enhancing lymphatic drug transport. We believe that a full understanding of their contribution to intestinal drug translocation will lead to effective oral delivery with liposomal formulations.
منابع مشابه
DESIGN OF LIPID-BASED DELIVERY SYSTEMS FOR IMPROVING LYMPHATIC TRANSPORT AND BIOAVAILABILITY OF DELTA- TOCOPHEROL AND NOBILETIN By CHUNXIN XIA
OF THE THESIS ....................................................................................... ii ACKNOWLEGEMENT.................................................................................................. iv TABLE OF CONTENTS ................................................................................................. v LIST OF TABLES ..............................................
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